Neuroscience

The human brain is made up of 80-100 billion number of cells called neurons, each of which makes connections to 1000 other cells making a total of 100 trillion connections in the brain. These junctions are called synapses and are the means by which signals are transmitted throughout the brain. In these synapses, receptors are optimally positioned to receive a signal by scaffolding molecules, which dock the receptors.. The Selvin lab is interested in this molecular organization of the synapse and the mechanisms behind how these synapses “learn” and “forget”. To do this we use the super resolution methods PALM and STORM.

Related Publications:

  1. Sang Hak Lee, Chaoyi Jin, En Cai, Pinghua Ge, Yuji Ishitsuka, Kai Wen Teng, Andre A. de Thomaz, Duncan L. Nall, Murat Baday, Okunola Jeyifous, Daniel Demonte, Christopher M. Dundas, Sheldon Park, William N. Green, Paul R. Selvin.  “Super-resolution Imaging of Synaptic and Extra-synaptic Pools of AMPA Receptors with Different- sized Fluorescent Probes”, eLife, July 26, 2017. eLife 2017;6:e27744 DOI: 10.7554/eLife.27744
  2. En Cai, Pinghua Ge, Sang Hak Lee, Okunola Jeyifous, Yong Wang, Yanxin Liu, Katie M. Wilson, Sung Jun Lim, Michelle A. Baird, John E. Stone, Kwan Young Lee, Michael W. Davidson, Hee Jung Chung, Klaus Schulten, Andrew M. Smith, William N. Green, Paul R. Selvin, “Stable small quantum dots for synaptic receptor tracking on live neurons.” Angewandte Chemie International Edition, Vol. 53 12484-12488.  Laser Focus World Article (2014) Supplementary Information.